Right approach to treatment. Right when they need it.
Findings from the Duchess study led to changes in treatment decisions and reduced recommendations for radiation therapy—helping patients avoid overtreatment.1
- After Breast DCIS Score® testing, 35% of patients had a change in treatment recommendation
- Radiation therapy recommendations dropped from 79% to 50% after testing
- Testing was associated with improved patient satisfaction and reduced decisional conflict
About the DCIS studies
Two validation studies confirm that the Oncotype DX Breast DCIS Score test determines the 10-year risk of local recurrence.
Studies involved 1,587 patients
Studies showed that clinicians could more accurately assess patient risk with the Breast DCIS Score test than with traditional assessment methods (such as clinical and pathologic factors or nomograms) alone1,4,5
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ECOG E5194: Breast DCIS provides individualized estimates of 10-year local recurrence risk
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Ontario DCIS cohort: confirmation that Breast DCIS stratifies patients based on risk of local recurrence
These studies confirmed that the DCIS Score result1,4,5:
- Reveals the 10-year risk of local recurrence in patients with DCIS who underwent breast-conserving surgery with or without XRT
- Is significantly associated with risk of an invasive local recurrence
- Is significantly associated with risk of a DCIS local recurrence
Meta-analysis of validation studies
A meta-analysis was conducted to provide refined estimates of local recurrence risk, combining data from the 2 validation studies and integrating the effect of patient age and tumor size.
This analysis showed7:
- DCIS Score result and clinicopathologic features (tumor size, age at diagnosis, and year of diagnosis) contribute to the prognostic value of the 10-year risk of local recurrence estimate
- The DCIS Score result contributes significantly to the prognostic value of the 10-year risk of invasive local recurrence
- Improved assessment of local recurrence risk with combined DCIS Score-tumor size-age vs either DCIS Score result alone or tumor size-age
- Using DCIS Score result with tumor size and age, more women at higher risk of local recurrence are identified
- Using DCIS Score result with tumor size and age, more women at lower risk of local recurrence are identified
Support your decision-making process with the Breast DCIS Score Test
Identifies more patients with very low risk of local recurrence7*
| DCIS Score result with tumor size and age |
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| DCIS Score result only | |||||||
| Tumor size and age only | |||||||
Identifies more patients at higher risk of local recurrence7*
| DCIS Score result with tumor size and age |
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| DCIS Score result only | |||||||
| Tumor size and age only | |||||||
*Meta-analysis prediction for 10-year local recurrence risk, adjusted for diagnosis year of 2000 or later.
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References
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